DNA replication origins, ORC/DNA interaction, and assembly of pre-replication complex in eukaryotes
نویسندگان
چکیده
منابع مشابه
DNA replication origins, ORC/DNA interaction, and assembly of pre-replication complex in eukaryotes.
Chromosomal DNA replication in eukaryotic cells is highly complicated and sophisticatedly regulated. Owing to its large size, a typical eukaryotic genome contains hundreds to tens of thousands of initiation sites called DNA replication origins where DNA synthesis takes place. Multiple initiation sites remove the constraint of a genome size because only a certain amount of DNA can be replicated ...
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The mini-chromosome maintenance proteins Mcm2-7 are essential for DNA replication. They are loaded onto replication origins during G1 phase of the cell cycle to form a pre-replication complex (pre-RC) that licenses each origin for subsequent initiation. We have investigated the DNA elements that determine the dependence of yeast replication origins on Mcm2-7 activity, i.e. the sensitivity of an...
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ژورنال
عنوان ژورنال: Acta Biochimica et Biophysica Sinica
سال: 2010
ISSN: 1672-9145,1745-7270
DOI: 10.1093/abbs/gmq048